Cell sugar concentrations affect hyaluronan production and cancer growth

Public release date: 27-Feb-2013
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Contact: Kirsi Rilla
kirsi.rilla@uef.fi
358-403-553-218
University of Eastern Finland

According to a recent University of Eastern Finland (UEF) study, elevated cell sugar concentrations increase the production of hyaluronan which, in turn, promotes cancer growth. Regulating the production of hyaluronan may be a way to prevent the spreading of cancer.

Hyaluronan is a long, linear carbohydrate polymer present in the human body. It forms a coating on the surface of many cells and plays a key role in fetal development and in the maintenance of normal tissue balance.

Under normal circumstances, hyaluronan promotes tissue healing; however, it can also maintain inflammation and promote the growth of cancer cells. Due to its high water retention capacity, hyaluronan is widely used in cosmetics and also in the medical sector, for example in the treatment of osteoarthritis symptoms and in eye surgery. Hyaluronan injected into the human body for treatment purposes is not associated with cancer risk.

Cells produce hyaluronan with the help of three cell membrane enzymes (HAS1, HAS2 and HAS3), and the production process also needs glucose derivatives.

Hyaluronan synthase 1, i.e. the HAS1 enzyme, is the least well known of the hyaluronan-producing enzymes, and yet its role in cancer malignity seems to be greater than previously thought. Published in Journal of Biological Chemistry, the UEF study showed that HAS1 requires a higher sugar concentration for the production of hyaluronan than HAS2 and HAS3. This finding may be significant for fighting cancer, as cancer cells are known to thrive on blood glucose. Increased glucose levels can lead to increased production of hyaluronan which, in turn, promotes cancer growth. Increased hyaluronan levels have also been found in diabetics with increased blood sugar levels. Diabetics are known to have a higher risk for breast cancer.

HAS1 also plays a significant role in inflammation, because growth factors associated with inflammation mediation, e.g., interleukins, can increase its activeness. This finding constituted part of the doctoral study of Lic. Med. Hanna Siiskonen, which was recently examined at the University of Eastern Finland.

By regulating hyaluronan levels, it may be possible to prevent the progression of cancer and other pathologies. The first clinical trials involving enzymes which break down hyaluronan have been able to slow down the growth and movement of cancer cells and to enhance the effectiveness of cancer drugs.

At the UEF Institute of Biomedicine, the research group of Professor Raija Tammi and Professor Markku Tammi has been studying hyaluronan for 25 years already, and the group's research is internationally renowned. The group focuses on cell biological mechanisms which regulate hyaluronan production. Together with its partners, the group has established a link between increased hyaluronan levels and a negative cancer prognosis in many cancer types, such as breast, prostate, colon, uterine, lung and ovarian cancer.

###

Further information about the research group is available at: http://www.uef.fi/biolaaketiede/ha

For further information, please contact:

Kirsi Rilla, PhD, Docent (Cell Biology)
University of Eastern Finland
School of Medicine, Institute of Biomedicine
Tel. +35840-3553218
email: kirsi.rilla@uef.fi

---

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 27-Feb-2013
[ | E-mail | Share ]

Contact: Kirsi Rilla
kirsi.rilla@uef.fi
358-403-553-218
University of Eastern Finland

According to a recent University of Eastern Finland (UEF) study, elevated cell sugar concentrations increase the production of hyaluronan which, in turn, promotes cancer growth. Regulating the production of hyaluronan may be a way to prevent the spreading of cancer.

Hyaluronan is a long, linear carbohydrate polymer present in the human body. It forms a coating on the surface of many cells and plays a key role in fetal development and in the maintenance of normal tissue balance.

Under normal circumstances, hyaluronan promotes tissue healing; however, it can also maintain inflammation and promote the growth of cancer cells. Due to its high water retention capacity, hyaluronan is widely used in cosmetics and also in the medical sector, for example in the treatment of osteoarthritis symptoms and in eye surgery. Hyaluronan injected into the human body for treatment purposes is not associated with cancer risk.

Cells produce hyaluronan with the help of three cell membrane enzymes (HAS1, HAS2 and HAS3), and the production process also needs glucose derivatives.

Hyaluronan synthase 1, i.e. the HAS1 enzyme, is the least well known of the hyaluronan-producing enzymes, and yet its role in cancer malignity seems to be greater than previously thought. Published in Journal of Biological Chemistry, the UEF study showed that HAS1 requires a higher sugar concentration for the production of hyaluronan than HAS2 and HAS3. This finding may be significant for fighting cancer, as cancer cells are known to thrive on blood glucose. Increased glucose levels can lead to increased production of hyaluronan which, in turn, promotes cancer growth. Increased hyaluronan levels have also been found in diabetics with increased blood sugar levels. Diabetics are known to have a higher risk for breast cancer.

HAS1 also plays a significant role in inflammation, because growth factors associated with inflammation mediation, e.g., interleukins, can increase its activeness. This finding constituted part of the doctoral study of Lic. Med. Hanna Siiskonen, which was recently examined at the University of Eastern Finland.

By regulating hyaluronan levels, it may be possible to prevent the progression of cancer and other pathologies. The first clinical trials involving enzymes which break down hyaluronan have been able to slow down the growth and movement of cancer cells and to enhance the effectiveness of cancer drugs.

At the UEF Institute of Biomedicine, the research group of Professor Raija Tammi and Professor Markku Tammi has been studying hyaluronan for 25 years already, and the group's research is internationally renowned. The group focuses on cell biological mechanisms which regulate hyaluronan production. Together with its partners, the group has established a link between increased hyaluronan levels and a negative cancer prognosis in many cancer types, such as breast, prostate, colon, uterine, lung and ovarian cancer.

###

Further information about the research group is available at: http://www.uef.fi/biolaaketiede/ha

For further information, please contact:

Kirsi Rilla, PhD, Docent (Cell Biology)
University of Eastern Finland
School of Medicine, Institute of Biomedicine
Tel. +35840-3553218
email: kirsi.rilla@uef.fi

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-02/uoef-csc022713.php

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Maize 'was key in Andean society'

25 February 2013 Last updated at 22:57 ET By Mark Kinver Environment reporter, BBC News

New evidence strengthens the argument that maize played an important role in ancient Peruvian civilisation 5,000 years ago, a study has said.

Samples taken from pollen records, stone tool residues and fossilised faeces suggest the food crop was actively grown, processed and eaten.

The authors say it adds more weight to the argument that Andean society was agricultural, not maritime-based.

The findings appear in the Proceedings of the National Academy of Sciences.

"If you look at the origins of civilisations around the world - from Egypt to China and India - they are all based on agriculture," explained co-author Jonathan Haas from The Field Museum, Chicago.

However, he told BBC News that an idea emerged that Andean early civilisation was different, and evolved from exploiting marine resources.

Power struggle

He told BBC News: "That theory has now been the dominant theory since the mid-1970s but more data has become available saying that there are not just [coastal] sites but there are some big inland sites too.

"People started to find corn at the inland sites, and the argument was that the corn was really a condiment and used for ceremonial purposes.

Dr Haas said that the findings from the team's study "topples that notion".

In their paper, the team explained that the first stage of identifying the botanical remains taken from the archaeological sites was the analysis of the macrobotanical (visible to the naked eye) artefacts.

"Analyses of hundreds of samples? revealed that macroscopic remains of maize - including kernels, leaves, stalks and cobs - were rare," they wrote.

They added that the reason for the lack of such samples at the sites has "yet to be resolved", but the lack of such remains could not be seen as evidence of the absence of maize.

"It is also possible that the lack of macroscopic remains is a reflection of limited excavations at these sites, given that the more extensive excavation of sites? did yield much more macroscopic evidence of maize."

Microscopic bounty

The team commented that the scarcity of macroscopic remains was in marked contrast to an abundance of microscopic evidence of maize in the guise of maize pollen samples collected from soil at the sites.

Although there was a possibility of contamination from modern sources, the team said that there were three factors that weighed against this.

"First, modern maize pollen grains are larger and turn red when stain is applied, whereas ancient grains do not," they said.

"Second, extraction of pollen samples followed standard archaeological guidelines and all crew members were trained in taking pollen samples.

"Third, the modern samples all contained pollen from a plant not found in the area prehistorically."

Dr Haas said that the pollen record gathered from the study sites was unequalled, with the data being accessed by other scientists in their research projects.

Other artefacts the team examined included 14 stone tools, which were radiocarbon-dated to between 2090 and 2540BC.

"Eleven of the 14 tools had predominantly or exclusively maize starch grains on the working surfaces, and two working surfaces had maize phytoliths (mineral excretions by the plant)," they recorded.

The researchers also found samples of sweet potato and bean starch grains.

The team also recovered 62 coprolites (fossilised faeces), of which 34 were human specimens.

They wrote that 69% of the specimens contained maize starch grains, the dominant source of starch in the diet at that time.

Dr Haas observed: "Maritime resources were important as it was their primary source of protein. But in each one of those coprolites, there was, on average, half an anchovy - that is not your diet, that is a condiment.

"In contrast, finding corn, beans, sweet potato and a number of other things in the diet - that is an agriculturally-based society."

He added that a vibrant agriculture system would result in a surplus of food, allowing the societal leaders to attract outsiders to the area and exert power.

The team wrote: "It was during this time that large permanent communities were settled, monumental architecture first appeared on the landscape, agriculture was more fully developed and indicators of a distinctive Andean religion are manifest in the archaeological record."

Source: http://www.bbc.co.uk/news/science-environment-21573875#sa-ns_mchannel=rss&ns_source=PublicRSS20-sa

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HBT: Billingsley takes hill for first time since injury

Today was a big day for Chad Billingsley, as he made his first appearance since he was shut down last August with a partially torn ulnar collateral ligament in his right elbow.

Billingsley was roughed up by the Cubs in the first inning, allowing two doubles, a home run and a single to the four batters he faced, resulting in two runs crossing the plate. However, he settled down from there, giving up just one more hit over his two innings of work while striking out one and walking none.

Billingsley made it through the outing unscathed and told Eric Stephen of True Blue L.A. that the shaky first inning was likely because he was too amped up for his first game action in six months.

?It?s good to be out there. In the first inning I had a lot of adrenalin. It seemed like forever since I last pitched in a game,? Billingsley said. ?Today I had a little bit more adrenalin than usual for spring training. Just coming back it felt great to be out there competing in a game situation.?

For now, Billingsley is hopeful that a pair of platelet-rich plasma injections will be enough for his elbow to hold up to the rigors of the season. If he has any setbacks, he will likely face Tommy John surgery. The Dodgers at least have some rotation depth with Chris Capuano and Aaron Harang if that comes to pass, though both pitchers are also potential trade chips.

Source: http://hardballtalk.nbcsports.com/2013/02/25/chad-billingsley-has-first-game-action-since-rehabbing-partially-torn-elbow-ligament/related/

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Paragliders Redefine Camping Trips | Stuff.co.nz

Pair paraglide South Island trip

JAMES GREENLAND

THOMAS DE DORLODOT

Camping with grace, Thomas de Dorlodot and Ferdinand Van Schelven are paragliding the length of the South Island.

THOMAS DE DORLODOT

AERIAL EXPLORERS: Ferdinand Van Schelven and Thomas de Doorlot.

If adventurer Tom de Dorlodot had a day job in New Zealand, his office would be hanging beneath a paraglider, thousands of metres in the air above the Southern Alps.

"It's the ultimate freedom. It's a beautiful way to travel, because you're not disturbing anything. Even the birds come and fly with."

The Belgian man and his Dutch friend Ferdinand van Schelven are professional paragliders who have landed in Nelson after a month-long adventure through the Southern Alps.

Their sport is vol-bivouac, literally "fly-camping" in French, which is riding a current of popularity overseas and could, according to the Red Bull-sponsored pilots, take off big in New Zealand.

Starting on a mountain peak in Otago and ending on a beach near Nelson, the pair have paraglided and walked nearly the length of the South Island, carrying with them just a parachute, some camping gear, and a pair of quickly worn-out walking boots.

"Either you walk, and you have to carry your paraglider; or you fly, and your paraglider carries you," de Dorlodot said, describing their 800km trip up the island.

Carrying less than 20kg of gear, de Dorlodot and van Schelven took 27 days to traverse the backbone of the South Island, from Te Anau to Nelson. Along the way they fished for trout in tranquil back country streams, drank glacier water fresh from the source, and soared with the birds above Aoraki/Mt Cook.

It was "a beautiful idea" coming to New Zealand, de Dorlodot said. Every morning the pair would wake, climb 2000-odd metres up a mountain, and jump off with their paragliders.

Once airborne their trick was to traverse the alps from above, flying as far as they could on thermal currents and friendly breezes. Eventually they would land, sleep in a hut or wrapped in the warmth of their 'chutes, then repeat the process.

"On a good day, if you don't have wind coming into the face and you can fly fast, you can cover up to 100 kilometres," de Dorlodot said. "Some days we fly 40 kilometres over two mountain passes that would have been four days of walking, and we do it in hours.

"When you know you have 100km to walk if you land, it's quite good motivation for flying and pushing yourself a little bit."

Unable to glide into Air Nelson airspace, they walked the final 75km north from St Arnaud.

"We said the stop was the sea. When we came in between Richmond and Nelson we arrived at the beach and said that's it," de Dorlodot said.

"That's a pretty good feeling, knowing you have crossed the whole thing with just a pair of shoes and a paraglider."

De Dorlodot and van Schelven are training for the "vol-biv" world championship - the RedBull X-Alps mountain race between Saltzburg, Austria and Monaco - in July. Competitors travel by air or by foot through 800km of hostile European alpine terrain.

New Zealand had been sweet for finding unique take-off locations, de Dorlodot said, as nearly every peak they jumped off was a world-first. He said Nelson, with its surrounding mountains and prevalent sea-breezes, could become a centre for the growing sport, which is primarily based out of Europe and throughout the sub-Asian ranges.

Van Schelven had flown in Nelson five years ago, when he dominated a competition, winning five-out-of-six "vol-biv" events.

When de Dorlodot isn't flying he is thinking about it. His RedBull sponsored Search project sends him around the world for a living, looking for the best places to vol-biv. Last year he crossed the length of Africa, soaring over the pyramids and Victoria Falls. His proudest achievement was gliding at 7200m to within 1km of the K2 summit in Pakistan.

"I think maybe it would have been possible to soar up. But, I didn't dare to. It has never been done. I was alone there, even a little scared, so I kept a respectful distance."

- ? Fairfax NZ News

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Source: http://www.stuff.co.nz/nelson-mail/news/8352866/Paragliders-redefine-camping-trips

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Palestinians call for probe of Israeli prisons

RAMALLAH, West Bank (AP) ? Palestinians on Sunday called for an international investigation of Israel's treatment of Palestinian detainees after a 30-year-old prisoner died in custody and a hunger strike by four other inmates sparked a week of West Bank protests.

The death of Arafat Jaradat set off more clashes between Israeli troops and Palestinian stone-throwers in several areas of the West Bank on Sunday. In one incident, two Palestinians were wounded by army fire, including a 15-year-old boy who was shot in the chest, a Palestinian health official said.

Jaradat's death raised new questions about Israel's Shin Bet security service, which has been accused by rights groups of mistreating Palestinians during interrogation.

Palestinian officials and the detainee's family alleged Jaradat was mistreated by the Shin Bet, saying he was healthy at the time of his arrest last week.

Israeli officials said Jaradat died of an apparent heart attack and denied he was beaten or subjected to any treatment that could have led to his death.

Israel's main forensics institute performed an autopsy Sunday, with a Palestinian physician in attendance.

Issa Karake, an official in the Palestinian Authority, said the Palestinian doctor told him afterward there was no sign of a heart attack and that Jaradat was tortured. Karake said he was told that the detainee had suffered two broken ribs and bruises.

The Israeli health ministry, however, said no external signs of violence were found on the body, aside from those likely caused during efforts to resuscitate him. The statement said the broken ribs likely resulted from intense resuscitation. The initial results of the autopsy could not definitively conclude the cause of death.

Several thousand Palestinian prisoners held by Israel observed a one-day fast to protest Jaradat's death. Jaradat, a father of a 4-year-old daughter and 2-year-old son, worked as a gas station attendant and his wife, Dalal, is pregnant, relatives said.

The fate of prisoners is an emotional issue for Palestinians and Israelis.

Virtually every Palestinian family has seen a member imprisoned since Israel captured the West Bank, Gaza and east Jerusalem in 1967, and the prisoners are generally seen as heroes resisting Israeli occupation. Many Israelis tend to view Palestinians involved in politically motivated violence as terrorists.

In the West Bank's largest city, Hebron, dozens of Palestinians threw stones at Israeli soldiers who fired tear gas and rubber-coated steel pellets. Stone-throwing protests also erupted near Jaradat's village of Saeer in the West Bank and near a West Bank checkpoint that is close to an Israeli prison.

In all, Israel holds close to 4,600 Palestinians on a range of charges, from throwing stones at Israelis to involvement in deadly shooting and bombing attacks. Of the detainees, 159 are being held without charges or trial in so-called administrative detention.

The Shin Bet said Jaradat was arrested last Monday, after residents of his village said he was involved in a rock-throwing attack that injured an Israeli. Jaradat admitted to the charge, as well as to another West Bank rock-throwing incident last year, the Shin Bet said.

The agency said that during interrogation, he was examined several times by a doctor who detected no health problems. On Saturday, he was in his cell and felt unwell after lunch, the agency said. "Rescue services and a doctor were alerted and treated him, they didn't succeed in saving his life," the statement said.

Jaradat's attorney, Kamil Sabbagh, said his client told an Israeli military judge during a hearing on Thursday that he was being forced to sit for long periods during interrogation. He also complained of back pain and seemed terrified to return to the Shin Bet lockup, but did not have any apparent signs of physical abuse, Sabbagh said.

After the court hearing, the judge ordered Jaradat to be examined by a prison doctor.

Karake, who handles Palestinian prisoner issues, said he holds Israel responsible for Jaradat's death, alleging ill-treatment and medical negligence. Karake called for an independent international investigation of Israel's treatment of Palestinian detainees.

The Israeli human rights group B'Tselem also demanded an investigation, including how Jaradat was questioned.

The agency routinely holds detainees in isolation for extended periods during interrogation, keeping them in cells that are lit around the clock and denying them access to lawyers, said Sarit Michaeli, a spokeswoman for the group.

She said that physical mistreatment of detainees had dropped sharply in recent years, but has not disappeared, according to affidavits by released prisoners. She also said detainees have filed some 700 complaints about mistreatment by Shin Bet agents during the past decade, but that none has led to a criminal investigation.

Jaradat's death comes at a time of daily Palestinian demonstrations in support of prisoners, especially four hunger strikers. The health of one of the hunger strikers has deteriorated.

In recent days, protests often turned into violent clashes with soldiers.

Defense officials said Chief of Staff Lt. Gen. Benny Gantz convened top military officials Saturday night to discuss escalating tensions in the West Bank.

___

Associated Press writers Ian Deitch in Jerusalem and Nasser Shiyoukhi in Saeer, West Bank, contributed to this report.

Source: http://news.yahoo.com/palestinians-call-probe-israeli-prisons-111912052.html

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Refresh Roundup: week of February 18th, 2013

Your smartphone and / or tablet is just begging for an update. From time to time, these mobile devices are blessed with maintenance refreshes, bug fixes, custom ROMs and anything in between, and so many of them are floating around that it's easy for a sizable chunk to get lost in the mix. To make sure they don't escape without notice, we've gathered every possible update, hack, and other miscellaneous tomfoolery we could find during the last week and crammed them into one convenient roundup. If you find something available for your device, please give us a shout at tips at engadget dawt com and let us know. Enjoy!

Filed under: Cellphones, Software, Mobile

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/iUjNzSD1Ovw/

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DC 'Reviewing' Firefighters' Appearance With Obama

The District of Columbia's Fire and Emergency Medical Services says there are no plans to punish first responders for their participation in an economic speech by President Obama, but are still reviewing the event.

Earlier this week, Obama surrounded himself with police and other first responders during remarks regarding the real world impact of the across-the-board package of federal spending cuts known as sequestration, looming in March should Congress fail to reach a deficit reduction agreement. But Washington's fire and EMS chief told a local TV station the appearance of three firefighters at the event may have violated department regulations.

"I didn't know about it, the deputy mayor didn't know about it, the mayor didn't know about it," Chief Kenneth Ellerbe said. "There should be protocol followed anytime one of our employees representing the District of Columbia appears at a public event."

Ellerbe told WRC-TV the employees had been ordered to file special testimonies on how they became guests of the White House event and who authorized it. The news report prompted a statement from the city government Friday.

"Contrary to reports in local media, the DC Fire and EMS Department is not considering any disciplinary action against uniformed personnel for appearing alongside President Obama," reads the Friday-night release, adding "DC FEMS is simply reviewing its internal protocols for such appearances to ensure that both the Department and its employees are fully informed."

"We fully support the efforts of President to highlight the essential and life saving work that our first-responders do every single day, and welcome his invitation for our members to participate," the statement said. "We're exceedingly proud of the men and women that wear the DC FEMS uniform, and thank the President for his support."

An after-hours inquiry to the department was unanswered as of press time.

Capt. Ed Smith, president of the DC Firefighters Association Local 36, said said it is not likely the department will actively discipline the members who participated in the Obama event, but he remains cautious over the broader implications of the review. The association president told ABC News the officers involved were off duty and that firefighters had routinely attended similar public events in the past without incident. The invitation came from the White House through Local 36's parent organization, the International Association of Firefighters.

"If it led to discipline later it would be taken as retaliatory," he said, adding he knew of no protocol breached by appearing in-uniform. "There is a pattern of retaliation with the chief and the department and that is a concern of mine."

Smith said he has seen such measures first-hand. In October an independent arbitrator ruled in favor of the captain's claim that he was involuntarily transferred due to his union activities.

The emergency services of the nation's capital have historically gone to good lengths attempting to appear neutral to the national politics embedded there. For example, the police and fire departments generally refuse to divulge crowd counts for the city's many protests and demonstrations. Any estimate given would likely be targeted as politically motivated.

Also Read

Source: http://news.yahoo.com/dc-reviewing-firefighters-appearance-obama-190600676--abc-news-politics.html

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Duracell Powermat adding mesh network, scaleable power to its wireless charging plates

Duracell Powermat is announcing a pair of new features to encourage sales of its wireless charging gear. The first is "Mesh Network," a set of controls that let multiple hotspots be centrally monitored -- so if you're stealing all the juice in the Wall St. Starbucks, central office can cut you off. On the upside, those same network features will enable you to find another charging hotspot on your smartphone, including Madison Square Garden and Jay-Z's 40/40 club. The second feature is that the latest mats will be able to vary the power on offer between 5 and 50 watts, making them capable of recharging smartphones, tablets and (potentially) Ultrabooks. Now all we have to do is work out how to power all of our electronics without arousing the suspicions of Jay-Z -- we'd hate to add a 100th problem to his worry list.

Filed under: Cellphones, Wireless

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/roEMfngYhIw/

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Three die in shootout, fiery crash on Las Vegas strip

LAS VEGAS (Reuters) - Three people died on the Las Vegas strip early on Thursday when gunmen in a Range Rover sport utility vehicle opened fire on a Maserati, killing the driver and touching off a fiery multi-car crash.

The driver of the Maserati was slain in the pre-dawn shooting, and his car collided with a taxi carrying two people, Las Vegas Metropolitan Police spokesman Officer Jose Hernandez said.

The cab exploded into flames in the intersection of Las Vegas Boulevard and Flamingo Road in front of several casino resorts, killing the driver and a passenger.

"They were trapped inside the taxi and tragically both lost their lives," Hernandez said.

The gunfire and collision in the busy intersection near the Bellagio and Caesar's Palace hotels triggered another crash involving four other vehicles that left at least four people injured, Hernandez said.

"There was a loud bang and I hear two other booms. I looked out my window at Caesars Palace ... and could see the fireball," witness John Lamb was quoted as saying on the news website of Las Vegas KLAS-TV's 8News Now.

Hernandez said investigators had not yet established a motive for the shooting or determined how many occupants of the Range Rover had opened fire on the Maserati.

The Range Rover sped from the scene. Hernandez said police had no leads on the suspects or their vehicle and were asking for help from the public. The intersection was expected to remain closed for much of Thursday due to the investigation.

An injured passenger in the Maserati and three people hurt in the crashes were taken to University Medical Center.

A hospital spokeswoman said three of the people had been treated and released. She declined to provide information about the fourth person.

The incident occurred not far from where rapper Tupac Shakur was shot in September 1996 while riding in a BMW being driven by Death Row Records co-founder Marion "Suge" Knight.

Shakur, 25, was hit by gunfire from at least one assailant in a Cadillac while sitting in Knight's car at the intersection of Flamingo Road and Koval Lane and died six days later at University Medical Center. The crime remains unsolved.

(Reporting by Tim Pratt; Additional reporting by Ian Simpson and Dan Whitcomb; Writing by Dan Whitcomb; Editing by Cynthia Johnston)

Source: http://news.yahoo.com/three-dead-car-car-shooting-las-vegas-strip-160434295.html

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How immigration threatens to tear the GOP apart

The Republican political establishment sees immigration reform as a political necessity. Much of the party?s base sees it as the end of the rule of law.

And therein lies the problem for a party trying to pick itself up off the mat following an across-the-board defeat in 2012.

Arizona Sen. John McCain is confronted on immigration during a town hall Tuesday. AP photo.

?The GOP faces a choice between the politics of math and the politics of anecdote,? explained Glen Bolger, a prominent Republican pollster. ?The politics of math is pretty clear. The numbers of Hispanics are growing, and politically we cannot afford to get a shrinking piece of a growing pie. The politics of anecdote is that illegal immigrants are only taking jobs, selling drugs, and joining gangs. That?s clearly not the case, and we cannot pretend that it is.?

Arizona Republican Sen.?John McCain?s testy townhall?typifies the divide between a party in Washington that, for the most part, simply wants to find a way to get to a ?yes? on immigration reform and an activist base who views that effort as contradictory to the foundational principles of the party.

McCain repeatedly sought to emphasize the need to find a responsible solution for the 11 million undocumented workers in the country but found himself shouted down and challenged by a handful of attendees.

While the back and forth between McCain and his constituents has drawn most of the attention, there?s ample evidence that there?s plenty of resistance among rank-and-file Republicans for the sorts of common-ground solutions that many of the party?s elected leaders seem set on pursuing.

In a Washington Post-ABC poll conducted earlier this month, in fact, a majority of self-identified Republicans said they opposed a path to citizenship ? the key plank of a comprehensive immigration reform measure. That was a marked contrast to the majority support for a path to citizenship among Democrats and independents.

Here?s the breakdown:

What those numbers suggest is that there could be primary trouble for Republicans who vote for any sort of comprehensive immigration reform plan that includes a path to citizenship. And that could be a major disincentive for GOP politicians to support such a proposal ? a short-term gain that would almost certainly provide longer-term pain for the party.

(We saw this sort of short-term political calculus during the 2012 GOP presidential primaries. Mitt Romney adopted a position that undocumented workers should ?self deport? in hopes of staying in the good graces of the party?s base. That position may have helped him win the primary, but cost him dearly in the general election as he won a meager 27 percent of Hispanic voters.)

It?s not clear how Republicans can bridge the growing divide between how the establishment views immigration (a political problem that needs to be solved yesterday) and how some significant portion of the base views it (a foundational principle about not rewarding rule-breakers).

Henry Barbour, part of a group within the Republican National Committee tasked with figuring out what went wrong in 2012 and how to fix it in future elections, says that the key to solving the party?s problems with Latinos is less about specific policies than about changing how the GOP talks to the Hispanic community.??Our issue with Hispanic voters is as much about tone and attitude as it is about immigration reform,? Barbour explains.

The problem inherent in that statement, of course, is that those willing to take the hardest line, rhetorically speaking, on immigration tend to win Republican primaries. And, politicians ? in both parties ? always put political survival ahead of all other concerns.

If Republicans go through another election cycle in 2014 in which candidates espousing strong opposition to any sort of compromise on immigration are rewarded by winning primaries, it could well do permanent damage to the party?s standing in the Hispanic community and, by extension, its paths to the White House in 2016 and beyond.

It?s no exaggeration then to say that getting immigration right, politically speaking, is absolutely critical to Republicans? electoral hopes over the next decade or more.

Fixbits:

Obama says he has a year to get his agenda done.

A reporter for the conservative Weekly Standard?tried to get access to Chuck Hagel?s archives?at the University of Nebraska-Omaha, but was turned away, since the archive has yet to open and won?t for another two years.

Actress and potential Kentucky Senate candidate Ashley Judd (D) has reportedly met with the DSCC.

Some Democrats?are calling for House Republicans to come back to Washington?and start working on a deal to avert the sequester.

Mitt Romney?will speak at?the Conservative Political Action Conference on March.

The DSCC raised $4.2 million in January.

Former congressman J.C. Watts (R-Okla.) is?launching an effort?to get congressional offices to hire more minority staffers.

Former New Orleans mayor Ray Nagin (D)?pleads not guilty?to corruption.

Must-reads:

?Can Republicans Win the Senate in 2014?? ? Nate Silver, New York Times

?All Signs Point to Kelly Victory in Illinois Special Election? ? Abby Livingston, Roll Call

?You May Be Right, Mr. President, But This Is Crazy? ? Ron Fournier, National Journal

?Brewing GOP Primary Could Spoil Landrieu Challenge? ? Joshua Miller, Roll Call

?Republican senator John McCain is still raising questions and hackles? ? Jason Horowitz, Washington Post

?Marco Rubio: The Electable Conservative?? ? Nate Silver, New York Times

?The GOP star you?ve never heard of? ? Alexander Burns, Politico

Source: http://www.washingtonpost.com/blogs/the-fix/wp/2013/02/21/how-immigration-threatens-to-tear-the-gop-apart/

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Raising NC tanning-bed age discussed in House

LONDON, Feb 19 (Reuters) - Arsenal 1 Bayern Munich 3 - Champions League last 16, first leg result At the Emirates Stadium Scorers: Arsenal: Lukas Podolski 55 Bayern Munich: Toni Kroos 7, Thomas Mueller 21, Mario Mandzukic 77 Halftime: 0-2 Teams: Arsenal: 1-Wojciech Szczesny; 3-Bacary Sagna, 4-Per Mertesacker, 6-Laurent Koscielny, 5-Thomas Vermaelen; 8-Mikel Arteta, 10-Jack Wilshere, 16-Aaron Ramsey (7-Tomas Rosicky 71), 19-Santi Cazorla; 9-Lukas Podolski (12-Olivier Giroud 72); 14-Theo Walcott Bayern Munich: 1-Manuel Neuer; 21-Philipp Lahm, 5-Daniel Van Buyten, 4-Dante, 27-David Alaba; 8-Javi ...

Source: http://news.yahoo.com/raising-nc-tanning-bed-age-210414315.html

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Putin: Archive could go to Jewish museum

MOSCOW (AP) ? Russian President Vladimir Putin is suggesting that a vast collection of Jewish books and documents that is the focus of a dispute between Moscow and Washington be given a permanent home in the Russian capital's new Jewish Museum.

A U.S. judge in January ordered that Russia be fined $50,000 a day until it turns over the so-called Schneerson Collection to Chabad Lubavitch, a Hasidic movement within Orthodox Judaism headquartered in Brooklyn, N.Y.

Russia claims the collection is state property. Putin on Tuesday criticized the ruling, saying "discussion of this problem has taken on elements of confrontation," Russian news agencies reported. The collection is now held at the state library and military archives.

Putin said he would consider ordering the collection be placed at the Jewish museum, which opened last year.

Source: http://news.yahoo.com/putin-archive-could-jewish-museum-191957656.html

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Mycestro Is A 3D Mouse For Your Fingertips That You?ll Look Funny Using, But Who Cares?

We all go through phases where we feel like we’ve seen every possible Kickstarter project that we’d ever want and then one like Mycestro comes along and reminds us that this is just the tip of the iceberg. It’s a 3D mouse that you strap to one of your fingers and it looks like it could become a huge asset for multi-tasking. If you think about how you use your computer, be it a desktop or laptop, you know that your hands move from the keyboard to the trackpad or mouse constantly, over and over again. It’s wasted movement for the most part, especially when you see the possibilities that Mycestro unlocks. The only thing left is for this thing to get funded, because it looks like all of the prototypes work perfectly. Its founder and creator, Nick Mastandrea, has been tinkering on this project for quite a while, having been featured in Engadget a few years ago, but it looks like it’s ready for primetime. You’ll be able to pick one up for a $79 pledge in white, or $99 with your choice of color. The estimated shipping date is sometime in October of this year, if all goes well. Have a look at some of its features, which include touch buttons that allow you to navigate your computer without the need of moving your entire and to a dedicated area on a computer, thanks to 3D technology and space recognition: Here are the specs for the 3D Mouse: - Size of a wireless earpiece. - Light, weighing next to nothing. - Internal battery can be charged via USB. - Battery life is estimated to be eight hours depending on usage. - Two different replaceable clip sizes. This isn’t a completely perfect situation though, as you’ll have to re-learn how to use a mouse. The other thing is that if you’re in a coffee shop or somewhere in public, people are going to look at you like you have some issues. The thing is called the Mycestro for a reason, it looks like you’re conducting your own private orchestra. In other words, you’re going to look weird. If you’re OK with that, then the benefits outweigh the public shame and looks you might receive. The device works from 30 feet away from your computer, thanks to bluetooth, so you could use this for presentations at work. The touch technology

Source: http://feedproxy.google.com/~r/Techcrunch/~3/dVbHPU5fz18/

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LG?s 5.5-inch Optimus G Pro phablet gets official

LG (066570) on Monday upped the ante in the ?phablet? wars by announcing the Optimus G Pro, a new smartphone that features a 5.5-inch display with a resolution of?1920 x 1080 pixels, a 1.7GHz quad core Snapdragon processor, a 13-megapixel rear-facing camera, a?3,140mAh battery and Android 4.1.2 Jelly Bean. Other key features of the device include the Dual Recording functionality that ?allows users to capture video with both the front and rear cameras simultaneously for a unique picture-in-picture experience,? and the Virtual Reality Panorama camera feature that ?allows shots of entire horizontal and vertical environments for a full 360o view.?

The Optimus G Pro is among the first of several phablets that are likely to come out in 2013 as vendors scramble to capitalize on the success that Samsung (005930) has had with its popular Galaxy Note series. LG says that the Pro will be available in Korea starting this week but hasn?t yet indicated when it will launch in other countries. The company?s full press release is posted below.

Optimus G Pro, LG?s first full HD smartphone, launches this week in Korea

LG?s 5.5-inch Full HD IPS Display Device to Make Appearance at MWC

SEOUL, Feb. 18, 2013 ? Hot on the heels of the success of Optimus G, LG Electronics (LG) today introduced the newest addition to the G family to the Korean public. With the largest display yet to appear on an LG smartphone, the 4G LTE-equipped Optimus G Pro with 5.5-inch Full HD IPS display and new UX features was developed to meet the growing demand for smartphones with large screens.

The Full HD IPS display on the Optimus G Pro ? developed in partnership with LG Display ? delivers 1920 x 1080 pixels at 400ppi. The smartphone offers the largest battery capacity in its class at 3,140mAh, allowing for Full HD viewing enjoyment for hours on end. And with an improved 13MP rear and 2.1MP front camera, users can also capture images and videos in Full HD, the same quality found on high-definition TVs.

The Optimus G Pro also comes with advanced UX features developed specifically for the device, such as Dual Recording and Virtual Reality (VR) Panorama. Dual Recording allows users to capture video with both the front and rear cameras simultaneously for a unique picture-in-picture experience. And VR Panorama allows shots of entire horizontal and vertical environments for a full 360o view. Creative and innovative UX features popular with Optimus G users have been added to the Optimus G Pro, such as an upgraded QSlide, Live Zooming and QuickMemo.

?The Optimus G Pro was developed specifically to deliver vivid and superb picture quality in a large display smartphone form factor,? said Dr. Jong-seok Park, president and CEO of LG Electronics Mobile Communications Company. ?We will continue to expand our position in the premium LTE smartphone segment with our superior display technology and unique user experience.?

Visitors to 2013 Mobile World Congress (MWC) can experience Optimus G Pro and its advanced UX features for themselves at LG?s Booth in Hall 3.

Optimus G Pro Key Specifications:
? Chipset: 1.7GHz Quad-Core Qualcomm? Snapdragon? 600 Processor
? RAM: 2GB DDR
? Memory: 32GB / microSD (up to 32GB)
? Display: 5.5-inch Full HD (1920 x 1080 pixels / 400ppi)
? Camera: Rear 13.0MP with LED Flash / Front 2.1MP
? OS: Android 4.1.2 Jelly Bean
? Battery: 3,140mAh (removable / wireless charging capable)
? Size: 150.2 x 76.1 x 9.4mm

Source: http://news.yahoo.com/lg-5-5-inch-optimus-g-pro-phablet-201610384.html

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'Activating' RNA takes DNA on a loop through time and space

Feb. 17, 2013 ? Long segments of RNA -- encoded in our DNA but not translated into protein -- are key to physically manipulating DNA in order to activate certain genes. These non-coding RNA-activators (ncRNA-a) have a crucial role in turning genes on and off during early embryonic development, researchers say, and have also been connected with diseases, including some cancers, in adults.

In an online article of the journal Nature, a team of scientists led by Wistar's Ramin Shiekhattar, Ph.D., detail the mechanism by which long non-coding RNA-activators promote gene expression. They show how these RNA molecules help proteins in the cell to create a loop of DNA in order to open up genes for transcription. Their experiments have also described how particular ncRNA-a molecules are related to FG syndrome, a genetic disease linked to severe neurological and physical deficits.

"These ncRNA-activators can activate specific genes by working with large protein complexes, filling in a big piece of the puzzle," said Shiekhattar, Herbert Kean, M.D., Family Professor and senior author of the study. "Our DNA encodes thousands of these ncRNA-activators, each with a role in timing the expression of a specific gene. As we learn more about non-coding RNA, I believe we will have a profoundly better understanding of how our genes function."

Their findings also provide a plausible mechanism of how locations along chromosomes, classically known as "enhancer" elements, can influence the expression ("reading") of genes located 5,000 to 100,000 base pairs ("letters") of DNA away. According to their findings, ncRNA-a molecules bind to large protein complexes to form a loop of DNA, which then opens up the gene to the molecular machinery that transcribes DNA. "There is an abundance of evidence to indicate that enhancers are critical components of transcription during embryonic development and disease process," Shiekhattar said.

"Non-coding RNAs are probably one of the earliest molecules that determine spatial and temporal gene expression in a developing embryo," Shiekhattar said. "These enhancers can help turn genes on and off as a growing embryo would need, but as we have seen in other genetic mechanisms of embryonic development, they can lead to cancer if they are switched on inappropriately in adult cells."

In the classic "central dogma" of biology, chromosomal DNA is transcribed into RNA, which is then translated by the cell into proteins. In recent years, however, scientists have found that not all transcribed RNA molecules become translated into proteins. In fact, studies have shown that large portions of the genome are transcribed into RNA that serve tasks other than functioning as blueprints for proteins.

In 2010, the Shiekhattar lab first published the discovery of these ncRNA enhancer molecules in the journal Cell (2010 Oct 1;143(1):46-58), and theorized on their role as "enhancers" of gene expression. Since then, laboratories around the world have published and linked ncRNAs not only to transcriptional enhancers but also to certain diseases, including some cancers.

To discover how such enhancer-like RNAs function, the Shiekhatter laboratory deleted candidate molecules with known roles in activating gene expression, and assessed if they were related to RNA-dependent activation. They found that depleting components of the protein complex known as Mediator specifically and potently diminished the ability of ncRNA-a to start the process of transcribing a gene into RNA. Further, they found that these activating ncRNAs can attach to Mediator at multiple locations within the Mediator protein complex, and Mediator itself can interact with the enhancer element site on DNA that encodes these activating ncRNAs. Their results also determined how mutations in a protein that makes up the Mediator complex, called MED12, drastically diminishes Mediator's ability to associate with activating ncRNAs.

Mutations in the MED12 protein are a marker for FG syndrome (also know as Opitz-Kaveggia syndrome), a rare genetic disorder that leads to abnormalities throughout the body and varying degrees of physical and neurological problems. "This clearly shows how activating ncRNAs can influence disease development, an idea that has been gaining evidence in the scientific literature," Shiekhattar said.

To confirm that ncRNA-a works with Mediator to form a loop in DNA, the researchers used a technique called chromosome conformation capture (3C) to gain a better understanding of the three-dimensional structure of chromosomes. Their results show how Mediator gets a foothold of sorts on the portion of DNA that encodes the ncRNA-a, and twists the DNA to form a loop.

"The looping mechanism serves to physically bring together a distant enhancer element with the start site of the targeted gene, allowing Mediator to recruit the proteins responsible for reading the gene to the location," Shiekhattar said. "It is at least one answer to how these classical enhancer elements function while being physically distant from their target genes."

The Philadelphia Inquirer discussed these findings with Shiekhattar, and he reveals why he refers to them views ncRNA-activators as the "dark matter of biology."

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Story Source:

The above story is reprinted from materials provided by The Wistar Institute.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Journal Reference:

1. Fan Lai, Ulf A. Orom, Matteo Cesaroni, Malte Beringer, Dylan J. Taatjes, Gerd A. Blobel, Ramin Shiekhattar. Activating RNAs associate with Mediator to enhance chromatin architecture and transcription. Nature, 2013; DOI: 10.1038/nature11884

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/lM5a2W4vYcE/130217134240.htm

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Google Friendly Packages Now Launched by KJ SEO

Chennai, India, February 17, 2013 --( PR.com )-- Adopt or perish seems to be the new mantra in the SEO world. With Google launching its period updates, SEO companies are now relying more and more on the best practices enforced by the...

Chennai, India, February 17, 2013 --(PR.com)-- Adopt or perish seems to be the new mantra in the SEO world. With Google launching its period updates, SEO companies are now relying more and more on the best practices enforced by the webmaster's guide. KJ SEO, a leading SEO service provider has announced the launch of its revamped and refurbished packages that are all in accordance to the guidelines set by Google.

Beside restyling their packages to suit the latest updates, KJ SEO has also launched an exclusive Google Friendly Package. Through this package, webmasters can make a slow yet sustained effort to naturally and organically promote the package. The tactic is to write an exclusive article and promote using different resource boxes, URL, and anchor tags. It also includes writing press releases and distributing them to the best press release directories and syndicating them so that they appear on Google news. "Through the entire project duration of 45 days, we include a little of all strategies that are Google friendly, so that your site is ready for all updates- present and future," says the spokesperson at KJ SEO.

It's not just the Google Friendly package that is geared to handle Panda and Penguin updates. "All our packages, be it Directory Submission, Local Business Marketing, SMO tactics, Lens Promotion, Infographic, etc. are designed to get the attention of Google spiders without violating the webmasters guidelines," says the spokesperson.

Google's latest updates have changed the way SEO was done. In fact, SEO can be categorized into to eras- an era prior to the Panda and Penguin updates, and the other after that. Today, it's no longer about submission; it's more about digital marketing as a whole.

"At KJ SEO, we have changed our SEO tactics to ensure that we are in sync with Google primary motive (that has never ever changed with changing times) - to keep the web clean," adds the spokesperson.

About KJ SEO:
KJ SEO is a SEO solutions provider that helps web owners with smart and sharp tools to promote their websites.

To know more, visit, http://www.kjseoservices.com

Contact Information:
KJ SEO Services
Kathir Esan
+91-44-428-211-57
Contact via Email
http://www.kjseoservices.com/
No.13, Selvi Nagar, 2nd St. Kolathur
Chennai
Tamil Nadu

Click here to read the full story: Google Friendly Packages Now Launched by KJ SEO

Press Release Distributed by PR.com

Source: http://news.brothersoft.com/google-friendly-packages-now-launched-by-kj-seo-64388.html

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Why Texas Gov. Rick Perry Was in Calif.

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// player.releaseUrl = "http://link.theplatform.com/s/Yh1nAC/"+nbcVideoPageUtils.videoReleaseId+"?mbr=true&manifest=m3u&assetTypes=LegacyRelease"; player.autoPlay = false; player.useDefaultPlayOverlay = true; player.bind("featuredPlayer"); //console.log("iOS player configuration complete!"); }); } nbcVideoPageUtils.videoReplay = function(targetScope) { nbcVideoPageUtils.countdownValue = 9; try { U.log("Attempting to clear timer."); clearTimeout(startTimer); clearInterval(ecCountdown); } catch(e) { U.log(e); U.log("Timer not present, moving on..."); } if(targetScope == null) { targetScope == "*"; U.log("nbcVideoPageUtils.videoReplay: WARNING: Scope not defined, defaulting to wildcard.") } jQuery('#endcard').fadeOut(); if($('.shareLink').hasClass('active')){ $('.shareLink').removeClass('active'); $('.linkBox').fadeOut('fast'); $('.linkBox .zclip').remove(); } if($('.shareEmbed').hasClass('active')){ $('.shareEmbed').removeClass('active'); $('.embedBox').fadeOut('fast'); $('.embedBox .zclip').remove(); } tpController.clickPlayButton(targetScope); } // START SOCIALIZE SHARE BAR ON ENDCARD function socializeEndcardShare(choseVideoUrl,choseOldSchoolUrl,choseCmsId,choseVideoTitle) { var uaEndcard = new gigya.socialize.UserAction(); var videoSummary = $(".feature_summary_top").find(".summary").text() // If oldschool url is not loaded from bottom list of videos // Then assumed it's the right-rail list of videos if (choseOldSchoolUrl == null || choseOldSchoolUrl == ""){ choseOldSchoolUrl = $("#featuredSummaryShare").find("span.featureContentOldSchoolUrl").html(); } var activityContext = new Object(); activityContext["ACTION_CONTEXT"] = "video_hub_endcard"; activityContext["ACTION_CONTENT_ID"] = choseCmsId; activityContext["ACTION_CONTENT_TITLE"] = encodeURI(choseVideoTitle); activityContext["ACTION_CONTENT_LINK"] = encodeURI(choseOldSchoolUrl); activityContext["ACTION_CONTENT_DESCRIPTION"] = encodeURI(videoSummary); activityContext["ACTION_ACTIVITY_FEED_ID"] = "www.nbcbayarea.com_2"; activityContext["USER_ACTION"] = uaEndcard; uaEndcard.setLinkBack(choseOldSchoolUrl); uaEndcard.setTitle(choseVideoTitle); // Define Share Bar plugin's Parameters var endcardShareParams ={ userAction:uaEndcard, shareButtons:[{provider:"facebook-like",tooltip:"Recommend this on Facebook",action:"recommend",width:"160",font:"arial"},{provider:"twitter-tweet",via:nbc.market,defaultText:window.document.title,countURL:encodeURI(choseOldSchoolUrl)},{provider:"google-plusone",size:"medium"}], containerID:'socialEndcardButtons' // location of the Share Bar plugin } // Load Share Bar plugin showShareBar(endcardShareParams,activityContext); } // END SOCIALIZE SHARE BAR ON ENDCARD nbcVideoPageUtils.goToNextClip = function(evt) { console.warn("nbcVideoPageUtils.goToNextClip: Is it an ad?"+evt.data.baseClip.isAd); if(evt.data.baseClip.isAd == false) { U.log("start timer "+startTimer); if( startTimer == 1 ) { if(jQuery('#feature_rr_list > li.next_playing').length > 0) { nextUpThumbnail = jQuery('#feature_rr_list > li.next_playing img').attr('src'); 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startTimeMS = (new Date()).getTime(); timerStep = 10000; startTimer = setTimeout("nbcVideoPageUtils.triggerNextClip()",10000); } else { jQuery('div.nextUp').hide(); jQuery('div.countdownContainer').hide(); } jQuery("#endcard").fadeIn("fast"); socializeEndcardShare(); forceEventHandlers(); /* if(timerPaused == false){ timerEventsOn(); }*/ embeddedPlayerHTML = '

View more videos at: http://nbcbayarea.com.

'; jQuery('.shareBoxes .linkBox fieldset').html(''+nbcVideoPageUtils.videoSocialShare+''); jQuery('.shareBoxes .embedBox fieldset').html(''+embeddedPlayerHTML+''); jQuery('#endcard div.countdownContainer span.countdown').html('10'); if(jQuery('#feature_rr_list > li.next_playing').length > 0) { ecCountdown = setInterval("nbcVideoPageUtils.endcardCountdown()",1000); } // dont put parsing of Social Widgets - WE have all together in one function } } } nbcVideoPageUtils.triggerNextClip = function() { try { U.log("Attempting to clear timer."); clearTimeout(startTimer); clearInterval(ecCountdown); } catch(e) { U.log(e); U.log("Timer not present, moving on..."); } U.log("Jump to next clip here."); try { triggerNextVideoTarget = jQuery('li.next_playing > a').attr('id'); jQuery('#'+triggerNextVideoTarget).trigger('click','autoplay'); jQuery('#'+triggerNextVideoTarget).trigger('click','autoplay'); jQuery("#endcard").fadeOut("slow"); //timerEventsOff(); if($('.shareLink').hasClass('active')){ $('.shareLink').removeClass('active'); $('.linkBox').fadeOut('fast'); $('.linkBox .zclip').remove(); } if($('.shareEmbed').hasClass('active')){ $('.shareEmbed').removeClass('active'); $('.embedBox').fadeOut('fast'); $('.embedBox .zclip').remove(); } } catch(e) { alert(e); } } nbcVideoPageUtils.countdownValue = 9; nbcVideoPageUtils.endcardCountdown = function() { if(nbcVideoPageUtils.countdownValue > 0) { U.log(nbcVideoPageUtils.countdownValue); if(nbcVideoPageUtils.countdownValue > 9) { jQuery('#endcard div.countdownContainer span.countdown').text(nbcVideoPageUtils.countdownValue); } else { jQuery('#endcard div.countdownContainer span.countdown').text('0'+nbcVideoPageUtils.countdownValue); } nbcVideoPageUtils.countdownValue-=1; } else { clearInterval(ecCountdown); U.log("Clear"); } } jQuery(document).ready(function() { if (navigator.userAgent.match(/like Mac OS X/i)) { // DO NOTHING } else { tpController.addEventListener("OnMediaEnd","nbcVideoPageUtils.goToNextClip"); } $('#endcard').css({'visibility':'visible','display':'none'}); $('.linkBox').css({'visibility':'visible','display':'none'}); $('.embedBox').css({'visibility':'visible','display':'none'}); }); //Timer pause functions for embed and link popups pauseTimer = function(){ clearTimeout(startTimer); clearInterval(ecCountdown); timerCount=0; remainingTime = timerStep - ((new Date()).getTime() - startTimeMS); timerStep = remainingTime; timerPaused = true; }; resumeTimer = function(){ if (!timerCount){ timerCount=1; timerPaused = false; startTimeMS = (new Date()).getTime(); startTimer = setTimeout("nbcVideoPageUtils.triggerNextClip()",remainingTime); ecCountdown = setInterval("nbcVideoPageUtils.endcardCountdown()",1000); } } //Pause and resume timer on window blur and focus (ie Facebook/Twitter login) var isIE = (navigator.appName == "Microsoft Internet Explorer"); function timerEventsOn(){ if (isIE){ document.onfocusout = function(){pauseTimer();} document.onfocusin = function(){resumeTimer();} } else{ window.onblur = function(){pauseTimer();} window.onfocus = function(){resumeTimer();} } } function timerEventsOff(){ if (isIE){ document.onfocusout = null; document.onfocusin = null; } else{ window.onblur = null; window.onfocus = null; } } //]]>

Source: http://feeds.nbcbayarea.com/click.phdo?i=03573631fbac85e2fb43fb7253013e76

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